Pearl Bio

Pearl Bio has developed a drug synthesis platform that allows tunable, template-directed synthesis of protein therapeutics. The biologic is first expressed in the Pearl Platform, which then genetically encodes and produces new types of protein polymers that can be subsequently and easily modified using click-chemistry. For example, facile fatty-acylation of the newly-encoded polymer can improve its half-life properties. Importantly, the platform allows for the introduction of many new chemical moieties with high yield and purity, all necessary for functionalization and production of protein biologics. This platform distinguishes itself by its ability to functionalize multiple different amino acids (AAs), make multiple modifications per polymer, and incorporate more exotic monomers using engineering ribosomes. It also provides for cell-free synthesis of biomaterials with multi-site AA and synthetic monomer incorporations at high yields, increasing the robustness of the platform further above its competitors.